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Part 2 with Joe DeVivo, the MedTech CEO who sold InTouch to Teladoc for over $1B and promised himself never to do another turnaround.

Two years later, the board of Butterfly Network called w/12mo cash left.

Here's how he did it.

Tom Bartlett spent 22 years inside the NHS. For three and a half years, he led the 150-person engineering team at NHS England that built the £330M Federated Data Platform with Palantir.

He left a month ago and he's the only insider speaking publicly about what the platform actually does, what it costs, and whether the NHS has any credible alternative.

We cover the architecture, the cost, the CLOUD Act, the BMJ exposé, the conflicts of interest at Chelsea & Westminster, and whether ministers should trigger the break clause.

Jared Dashevsky, MD (Healthcare Huddle) and Ala Alenazi, PhD (Kinnevik) join Mustafa to discuss:

1. The rise of the AI Broker (a middleman that's about to emerge)
2. Palantir's £330M NHS break clause
3. OpenAI as pharma. We also discuss why drug discovery needs a "Human Genome Project 2.0"

Jared Dashevsky, MD (Healthcare Huddle) and Ala Alenazi, PhD (Kinnevik) join Mustafa to discuss:

1. Healthcare spends 75% on services and 3–4% on IT -- yet every AI startup is pitching a copilot. Sequoia's new thesis: the next trillion-dollar healthcare company won't sell software at all. It'll just do the work.
2. The PCP Apocalypse. Urgent care has tripled, PCP density is down 22%, and behavioral health visits just overtook primary care. We debate whether the answer is more PCPs or changing the role.

1. Kalshi for clinical trials. A Stanford PhD built a public market where nine frontier AI models bet on Phase 3 outcomes. Ala calls it "capitalism's final boss" and explains why it might be the most dangerous innovation in pharma this year.

Jared Dashevsky, MD (Healthcare Huddle) and Ala Alenazi, PhD (Kinnevik) join Mustafa to discuss:

1. The wellness industry is now four times bigger than pharma -- and peptide parties are the new IV drip bars.
2. What's going on there? OpenEvidence built a $12B company on physician search, but everyone's copying the playbook. Is there any moat?
3. World models coming -- and why LLMs might not be enough to fix healthcare.

What can healthcare learn from Candy Crush? A lot. Jason Oberfest (VP Healthcare, Oura) used gaming psychology to build a first-of-its-kind digital health company (backed by Kleiner Perkins) — as well as roles at MySpace, Apple and more.

Now he's bringing that playbook to Oura, following their $11B valuation and booming growth.

Links

Jason Oberfest: https://www.linkedin.com/in/jasonoberfest/

Dr Mustafa Sultan: https://www.musty.io/

What does it take to build a $100M healthcare company? Honestly, no one really knows — and the people who do don't tend to talk about it.

But Steve Kraus and his team at Bessemer have actually studied it. They've analyzed hundreds of venture-backed healthtech companies and published the research.

In this episode, I pull six lessons from their work and ask Steve to explain them.

Links

Steve Kraus: https://www.bvp.com/team/steve-kraus

Dr Mustafa Sultan: ⁠⁠⁠⁠https://www.musty.io⁠

Music: “Habanera” by Kevin MacLeod

Licensed under Creative Commons Attribution 4.0

https://creativecommons.org/licenses/by/4.0/

Edited for length.

What actually happens after you sell a company for $1.1B and never need to work again?

Joe DeVivo is a legendary MedTech CEO who sold InTouch to Teladoc in a $1.1B deal and is now President, CEO, and Chairman of Butterfly Network.

Joe has a very specific reputation in the industry. He steps in when companies get stuck. Often at the moment when a founder-led business needs a different kind of leadership to scale. In this episode, Joe breaks down his turnaround playbook step by step, from how he diagnoses what’s broken, to who stays, who goes, and how focus gets restored.

He also opens up about something that’s rarely talked about. What it really feels like after a massive exit. When the money hits, the anxiety leaves your body, and you realize you never have to work again. What does “post-economic” life actually look like, and why do some people still choose to come back?

We also trace Joe’s path from growing up in a family-run manufacturing business to becoming the CEO boards call in moments of crisis, and why invention and scaling are fundamentally different jobs.

Links

Butterfly Network: https://www.butterflynetwork.com

Dr Mustafa Sultan: ⁠⁠⁠https://www.musty.io⁠

In 2023, Alexandre Lebrun pointed two exits in conversational AI at Medicine. Nabla raised $120M and spread to 130+ orgs and 85,000 clinicians in record time. 

But in the ambient AI game -- it seems like distribution beats all. How will Nabla win?

Links

Nabla: https://www.nabla.com/

Dr Mustafa Sultan: ⁠⁠⁠https://www.musty.io⁠

In 2017, Andrew Parker launched Papa with a 1-800 number, offering 'grandkids-on-demand' in Miami. By 2021, the company was valued at $1.4bn (backed by SoftBank and Tiger Global).

This is a YC-backed gig economy company operating in the regulated elder care market at unicorn scale.

On paper it shouldn't have worked -- and yet it did.

Links

Papa: https://www.papa.com/

Dr Mustafa Sultan: ⁠⁠⁠https://www.musty.io⁠

According to Business Insider, Omada Health has quietly filed its S-1 to prepare for an IPO. Here's how Sean Duffy (CEO & Co-founder) built it.

0:00 Intro

0:17 Signing first customer

1:51 How to have good ideas in healthcare

4:00 Why metabolic health is a hard area to innovate in

5:18 What the MVP product looked like

11:16 Sean's secret tactics

14:55 Operational innovation as a differentiator

20:19 The Omada playbook — is it repeatable?

25:31 What boss moves have you made Sean?

29:37 The difference between good and great

32:29 Sean's best tip on selling in enterprise healthcare

33:35 Sean's advice to himself

Links

Omada Health: https://www.omadahealth.com

Dr Mustafa Sultan: ⁠⁠https://www.musty.io⁠

Dr Aengus Tran is the CEO of Harrison.ai — an Australian radiology AI startup who have raised $160M.

Harrison.ai just released their radiology foundation model, Harrison.rad.1. And it's really good.

0:00 Intro

2:25 I'm glad I didn't found my startup in the US

4:21 Partnering with a clinical operator is key

7:28 Scrappy stories from the early days

11:17 Where human radiologists outperform AI (zero-shot learning)

17:23 Big bets on the future of radiology

21:18 What happens when GPT-8 arrives?

25:29 How can AI reach suprahuman radiology performance?

28:58 What boss moves did you make?

Links

Harrison.ai: ⁠https://harrison.ai⁠

Dr Mustafa Sultan: ⁠https://www.musty.io⁠

Michael Meucci (CEO) transformed Arcadia — formerly a mid-sized consultancy into a healthcare platform with $100M of Annual Recurring Revenue. How?

Lots of smart moves, including becoming really good at enterprise healthcare selling. Here's how he did it.

Links

Arcadia: https://arcadia.io/

Dr Mustafa Sultan: https://www.musty.io/

Dr Elina Berglund is the CEO/Co-founder of Natural Cycles, which she has grown to 2M users. When every other app seemed to be free — she made a brave decision: She charged her users a monthly fee. And it worked...

0:57 - The Birth of Natural Cycles 2:57 - The Decision to Charge from the Start 3:47 - Building Trust Through Pricing 4:23 - From Personal Struggles to Public Solution 5:52 - Creating the Fail-Safe Algorithm 6:32 - Collaboration with CERN Colleagues 7:13 - The Human Body: Complex Beyond Measure 8:37 - The Promise and Challenge of Wearables 10:16 - Understanding User Behavior 11:04 - Gaining Regulatory Approval 12:26 - Secrets to Growth and Marketing 13:43 - The Challenge of Direct-to-Consumer Healthcare 16:02 - Data-Driven Decision Making 17:13 - Instincts Versus Data 19:01 - Staying Honest with Data 21:20 - Calibrating Communication for Investors 22:30 - Benefits of Being Profitable 24:08 - Data as a Superpower 24:59 - Overcoming Negative PR 27:13 - Future of Contraception 29:30 - Impact of Roe v. Wade Overturning

Links

Natural Cycles: https://www.naturalcycles.com/

Dr Mustafa Sultan: https://www.musty.io/

Konstantin started Kaia Health after paying $50,000 to cure his back pain at an elite pain rehab centre. It worked. But it seemed stupid. Why did this need to cost $50,000?

Kaia Health has since raised $125M and helped 625,000 users.

0:00 The 90 second story

1:22 How did he grow 20% every week?

2:15 Market timing is everything

7:43 We never put pressure on this making any money

10:51 How does an app cure back pain?

14:43 US vs Germany for digital health entrepreneurs

16:40 Go to market of Kaia Health

19:51 Why raise so much money?

24:57 The hero license

Links

Kaia Health: https://kaiahealth.com/

Dr Mustafa Sultan: https://www.musty.io/

Jon Ronson is one of the most interesting people alive today — period. He’s the author of the Men Who Stare at Goats, So You’ve Been Publicly Shamed and The Psychopath Test — which spent 10 weeks on the New York Times bestseller list. His two Ted talks have been watched 20 million times, his books have been brought to life by George Clooney on the big screen, he has written screenplays for Netflix blah blah blah. Don’t believe me, listen to a pitch Jon wrote for ‘the Psychopath Test’. If you are not dying to hear what happens next — then, I don’t what to tell you…

0:00 Jon's pitch for the Psychopath Test

1:41 Jon's story

6:00 Strategies Jon used to bypass career gatekeepers

7:03 Would Jon Ronson be on Substack/podcasting

12:05 Does Jon Ronson pay attention to analytics? Post mortems

16:26 Startup philosophy applied to storytelling

19:08 Writing Advice from Tim Ferriss: Jon's opinion on doing interesting things to write better

24:59 Does Jon Ronson like being famous?

28:49 Analysis of 'The Psychopath Test' pitch to Ira Glass

37:30 Should you make decision based on what would be a good story

38:48 Jon Ronson's habits for creative success

Max Parmentier is the CEO of Birdie, a Series B AgeTech startup who have raised $52M from the likes of Sofina, Omers Ventures and Index Ventures — and captured 10% of the UK market whilst currently scaling into Europe.

0:00 Intro

2:37 Shopify vs Amazon model in AgeTech

7:26 Product pivots: D2C never wins

11:56 Predictive AI AgeTech

13:58 I pitch an idea to Max

19:34 Lessons building Birdie

24:13 Leaving money on the table for purpose

Links

Birdie: https://www.birdie.care/

Dr Mustafa Sultan: https://www.musty.io/

Tom Wicher is CEO of DrDoctor — who have served over 20M patients and just raised £10M in their recent Series A round. But he spent the first 7 years bootstrapping, and diverged from his colleagues: Opting for the slow and steady gentle disruption path. Why?

0:00 Gentle disruption beats move fast and break things

3:36 Picking a problem in healthcare

5:44 Behavioural change theory

7:52 Stop treating patients like kids

10:30 Systems-level efficiency vs personalisation

13:02 Why don't patients show up for their appointments?

16:02 Overbooking: Learning from airlines

18:54 Carrot or stick: Motivating health behaviors

22:35 There's no big conspiracy in healthcare

26:24 PIFU model of patient booking

28:14 Sometime it's better not to empower patients

31:16 Habits/frameworks that have helped Tom succeed

Links

DrDoctor: https://www.drdoctor.co.uk/

Dr Mustafa Sultan: https://www.musty.io/

Drug discovery is becoming more expensive and producing less results than ever before (Eroom's Law)—why? One of the ballooning costs are clinical trials. Pharma/biotech often outsource their trials to CROs (contract research organisations). But many CROs are incentivised to make trials as bloated and inefficient as possible. That means more money and less results. Meri Beckwith is building the anti-CRO: Lindus Health—to solve this problem.

0:00 Intro

1:39 The big problem in drug discovery

4:10 Why do CROs exist?

7:24 The incentive problem in drug discovery/CROs

10:57 Pharma are anti-startups

12:11 How much a clinical trial costs

15:11 How can you compete with big CROs?

17:26 Are you going to build your own drug pipeline?

18:56 Lessons from VC to Founder

23:42 Brand/PR/Positioning as a biotech startup

29:03 Billion dollar ideas in bio/health

31:33 Habits that have helped Meri

Links

Lindus Health: https://www.lindushealth.com/

Meri Beckwith: https://twitter.com/meribeckwith

Mithi Thaya: https://www.linkedin.com/in/mithi-thaya/

Dr Mustafa Sultan: https://www.musty.io/

Rewind.ai just raised their Series A at a valuation of $350M. Investors include Andreesen Horowitz, Reddit’s Alexis Ohanian and OpenAI’s Sam Altman. Rewind sits on your computer and phone, and watches everything you do. Then you can ask it questions like: What was that really great Mediterranean recipe I looked at last month? Or I’ve got a call with a client next week, can you summarise every interaction I’ve had with them? But here’s where it becomes even weirder, powerful. They’ve announced the Rewind Pendant, a small audio recorder that sits on your chest. Rewind will be able to listen in to every conversation you have. You can ask it: What birthday present should I get for my partner? Did they drop any hints? Or how many arguments did we have last year? Pretty Black Mirror, right? Once you get over the ick however, you realise that this is correcting a lagging human function. Just like the cursed amongst us wear glasses; tools like Rewind will repair our broken memories. I spoke to Dan Siroker, Rewind’s founder— 0:00 Intro 1:54 Lessons from the Obama Campaign 3:28 How to use science to make your startup succeed 8:21 Privacy concerns 17:00 Rewind.ai as a brain-computer interface (BCI) 20:27 Forgetting is important for human wellbeing 22:26 Societal impacts of perfect memory 28:42 Rewind's tech stack 31:56 The existential risk of startups using GPT 35:21 D2C is harder than B2B 37:49 Leadership lessons 40:31 Perils of being a second time founder 46:44 Is any publicity good publicity? Links Rewind: https://www.rewind.ai/ Dan Siroker: https://twitter.com/dsiroker Dr Mustafa Sultan: https://www.musty.io/

People are wearing Apple Watches to their wedding days. Has this whole 'quantified self' movement gone bananas? Is any of this data actually useful? I spoke to Maitham Dib about this. He's building Vital (YC21); a startup which makes all wearable/lab data available to other startups/companies. 0:00 Wearable data is mostly useless 3:22 The case for wearable data 6:37 Wearable data is mostly useless 8:06 Wearable data is useful 10:16 The big opportunity with wearable/lab data (startups) 14:15 Naivety as a superpower (Paul Graham) 15:45 Why building Vital is so hard 19:31 Pros/cons of an infrastructure play in healthcare 20:51 How to enterprise sales 24:09 Lessons from YCombinator 27:32 The benefits of being an immigrant Links Vital: https://tryvital.io/ Dr Mustafa Sultan: https://www.musty.io/

Dr Jared Dashevsky writes Healthcare Huddle (acquired by Workweek). He's scaled to over 30,000 subscribers. And it was pretty simple.

Here are 12 frameworks that work for healthcare content creation (and mistakes to avoid).

0:00 Intro

1:14 Consistency is king; systematise it

7:40 McKinsey reverse pyramid principle for writing

9:10 You need to have a unique/controversial take

11:41 Content for network building

15:51 Lean startup thinking does not work for content

20:35 Nobody cares about errors

25:52 Injecting personality is a competitive advantage

29:32 Boring content will make you rich

34:13 Don't make a useless audience; acquire data

41:19 Lessons from Jerry Springer

45:18 Hyperoptimisation paradox

48:49 Do things that don't scale

Links

Healthcare Huddle: https://workweek.com/brand/healthcare-huddle/ Dr Jared Dashevsky: https://twitter.com/jareddashevsky Dr Mustafa Sultan: https://www.musty.io/

Despite $billions of investment into the sector — there are still no AI discovered drugs on the market. Why? Recursion Pharmaceuticals (NASDAQ: RXRX) is one of the hottest AI drug discovery companies on the market. Especially after NVIDIA's $50M investment into them. Dr Imran Haque (SVP of AI and Digital Sciences) explains why AI drug discovery is so tricky — and when it's arriving. 0:00 Intro 0:42 Decoding biology (the big idea) 2:18 Why is AI drug discovery harder than it looks? 4:48 Simulating the Sims (game) vs AI drug discovery 6:58 Building data for AI drug discovery 14:47 Recursion's successes and failures 24:22 The barriers to AI drug discovery 26:45 How optimistic should we be about AI drug discovery 35:26 Being aggressively generalist for success People Dr Imran Haque: https://www.recursion.com/team-members/imran-haque Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Mustafa Sultan: https://www.musty.io/

0:00 NVIDIA's $50M investment into Recursion Pharmaceuticals 2:28 NVIDIA is becoming a seed investor 3:45 Bull case for Recursion Pharmaceuticals 9:20 Recursion's two big acquisitions 13:05 How are Recursion going to make money? 14:15 Recursion is overhyped 19:45 Recursion is unprofitable 22:21 Kim Kardashian's full body MRI scan 26:03 Longevity doctor's advice to Kim K 31:49 Speculating on Kim K's longevity regime (what she takes) 35:00 Outro and feedback Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicine Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health Dr Mustafa Sultan: https://www.musty.io/

Ever waited months for a scan? Scan.com is making getting a scan as easy as booking an Uber. Behind the scenes of the disruptor changing medical imaging forever. 0:00 Race to the bottom? 1:34 AirBnB 11 star framework 9:57 Scan.com looks really easy to build — what's hard about it? 12:19 Lessons from working at Deliveroo 15:14 How do you make a lot of money? 19:41 Buying the domain name Scan.com 24:16 How to build a marketplace business 27:50 The perils of price transparency 30:36 What I would do to build a competitor 32:43 You need grit when building a health startup 35:46 Billion $ health ideas Podcast Links YouTube: https://www.youtube.com/channel/UCEzluDRmBTVby0WsO37V-xg Apple: https://podcasts.apple.com/gb/podcast... Spotify: https://open.spotify.com/show/5707RPm... People Dr Mustafa Sultan: https://www.musty.io/ Charlie Bullock: https://scan.com/

0:00 David Sinclair's controversial claim 1:39 Bull v bear case 6:23 David Sinclair's history of exaggerating and profiteering 8:34 Adam Neuman's involvement 11:40 Raising from unsophisticated investors 16:30 Why aren't big pharma interested in longevity? 22:45 Cynics are right, optimists get rich 25:26 Will a longevity drug be the most valuable therapeutic ever made 28:52 Feedback and outro David Sinclair's Tweet: https://twitter.com/davidasinclair/status/1679178670743732249?s=20 David Sinclair's Research Paper: https://www.aging-us.com/article/204896/text Elon Musk Tweet: https://twitter.com/davidasinclair/status/1679504700285104129?s=20 Dr Charles Brenner's Critique of Sinclair: https://twitter.com/CharlesMBrenner/status/1679213673771057152?s=20 Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicine Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health Dr Mustafa Sultan: https://www.musty.io/

0:00 Why not let the builders build? Move fast and break things?

1:56 Why don't you ban people from googling their symptoms?

3:28 Is a disclaimer enough?

5:27 Why are LLMs difficult to regulate?

10:13 Move fast and kill patients — principal agent problem

12:23 People aren't idiots (they are)

14:20 Dr ChatGPT will never work

17:35 Spotting bubbles in healthcare

19:20 How much time does regulation add onto medical device approval?21:40 Can we ever regulate LLMs?

Podcast Links

YouTube: https://www.youtube.com/@bigpicturemedicineApple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262

Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a

People

Dr Hugh Harvey: https://www.hardianhealth.com/ Dr Mustafa Sultan: https://www.musty.io/

Daniel Ek (Spotify Founder) has raised $65M for his new longevity startup: Neko Health. 0:00 What is Neko Health 2:18 They're doing nothing new 5:33 The bull case; why it's going to be huge 7:47 How are they possibly going to make money!? 18:30 Why aren't they doing full body MRI? 20:26 The bear case; why this will fail 25:13 Smells a bit hypey 29:15 The risks of longevity startups and early testing 35:41 The lowdown 37:47 Unexpected way of making $$$ 40:00 Outro and feedback Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicine Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health Dr Mustafa Sultan: https://www.musty.io/

0:00 Leaked secret Apple health report

5:06 What Apple are up to in healthcare

9:21 Decentralised clinical trials

11:35 Apple healthcare leaked documents controversy

15:38 Apple is going to become a health insurer

23:07 Imran's advice to Tim Cook

26:11 Being a healthcare provider is unprofitable

28:12 Apple will make a longevity/subscription health play

30:27 Outro and feedback

Links mentioned

Apple Struggles in Push to Make Healthcare Its Greatest Legacy (Wall Street Journal): https://www.wsj.com/articles/apple-struggles-in-push-to-make-healthcare-greatest-legacy-11623832200

Podcast Links

YouTube: https://www.youtube.com/@bigpicturemedicineApple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262

Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a

People

Dr Imran Mahmud: https://www.imranmahmud.com/

Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health

Dr Mustafa Sultan: https://www.musty.io/

Huma is about to reach a 1 billion dollar valuation, and is thriving while other digital health companies are dying. But what’s their secret sauce? Dan Vahdat is the Johns Hopkins dropout — who meticulously studied the successful business practices of big pharma, and using these, has created the 'soonicorn' digital health company that’s about to take over the world of remote patient monitoring and decentralised clinical trials. 0:00 Intro 1:11 Focusing on one big thing is bullsh*t 6:33 Lessons from Jony Ive 10:02 Healthtech infrastructure play 16:04 'Ownership is everything' discussion 20:18 If you maximise impact, commercial will come 24:00 Bad design hurts me 28:56 You don't need to try and inspire anyone 30:35 Are you full of sh*t? 32:27 How does your life change when you 'make it'? 36:50 Is studying successful people a waste of time? 39:28 Outro Podcast Links YouTube:    / @bigpicturemedicine   Apple: https://podcasts.apple.com/gb/podcast... Spotify: https://open.spotify.com/show/5707RPm... People Dr Mustafa Sultan: https://www.musty.io/ Dan Vahdat https://www.huma.com/

0:00 Intro 1:04 The genius business model of GetHarley 5:26 How important is marketing? 50% of revenue 14:57 Why aren't they doing cooler more innovative stuff? 22:38 What verticals would we expand GetHarley's biz model to 24:37 Vitamin vs painkiller 27:49 Why have investors put so much money into GetHarley? 31:00 Feedback and outro Links mentioned GetHarley, a skincare telehealth and consultation platform, raises $52M (TechCrunch): https://techcrunch.com/2023/06/06/get... Podcast Links YouTube:    / @bigpicturemedicine   Apple: https://podcasts.apple.com/gb/podcast... Spotify: https://open.spotify.com/show/5707RPm... People Dr Imran Mahmud: https://www.imranmahmud.com/ Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health Dr Mustafa Sultan: https://www.musty.io/

0:00 Intro

0:20 DEA comes after DTC health startups

3:18 How DTC health startups hacked customer retention

10:30 Will this kill the economics of D2C health startups?

12:57 How would we solve the problem

15:30 New LLM Paper in Nature

28:18 Audience feedback and outro

Links Mentioned

Cerebral Pushed ADHD Prescriptions And Failed To Report Data Breaches, Ex-Executive Alleges In Lawsuit (Forbes): https://www.forbes.com/sites/katiejennings/2022/04/28/cerebral-pushed-adhd-prescriptions-failed-to-report-data-breaches-ex-executive-alleges-in-lawsuit/DEA's proposed telehealth rules pull back COVID-era remote prescribing flexibilities: https://www.fiercehealthcare.com/telehealth/deas-proposed-telehealth-rules-tighten-covid-era-remote-prescribing-regulations

DEA extends telehealth prescribing flexibilities for 6 months: https://www.fiercehealthcare.com/health-tech/telehealth-providers-cheer-dea-moves-temporarily-extend-virtual-prescribing

Health system-scale language models are all-purpose prediction engines (Nature): https://www.nature.com/articles/s41586-023-06160-y

Podcast Links

YouTube: https://www.youtube.com/@bigpicturemedicine

Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262

Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a

People

Dr Imran Mahmud: https://www.imranmahmud.com/

Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health

Dr Mustafa Sultan: https://www.musty.io/

Numan have raised $70M+ and are set to become the biggest men's digital health startup, ever. Here's how. From their eccentric Founder. 0:00 Intro 0:42 Valuation 1:46 Lessons from Calm.com 4:49 Raising aggressively 7:35 Successful entrepreneurs are not hyper intelligent 10:38 When to quit 14:43 The Social R Number 18:14 Being nice gets you nowhere 22:24 Numan's marketing genius 38:09 What Adam Neumann got wrong 45:12 Narrative is like really important 49:13 Being honest about your motivations 52:59 Outro Podcast Links YouTube: https://www.youtube.com/@bigpicturemedicine Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262 Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a People Dr Mustafa Sultan: https://www.musty.io Sokratis Papafloratos: https://www.numan.com

0:00 Intro

0:18 Ali Parsa's Immigrant Story

1:57 Picking a Problem That Was Too Big

4:15 The Supply Induced Demand Problem

5:55 The Unit Economics Problem

7:37 The Misaligned Incentives Problem

10:11 The Friction Problem

12:06 The First Mover Disadvantage

13:30 Raising Too Much Money

14:55 The SPAC Problem

17:40 The Pig With Lipstick Problem

22:07 Should Founders be Liberal with the Truth?

26:06 What Will the Next Health Unicorn Be?

Articles Mentioned

Babylon shareholders wiped out in restructuring deal: https://www.ft.com/content/ce42bcb7-d9ee-4667-910a-b6c7a419449b

Podcast Links

YouTube: https://www.youtube.com/@bigpicturemedicineApple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262

Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a

People

Dr Imran Mahmud: https://www.imranmahmud.com/

Dr Adam Bataineh: https://twitter.com/DrAdamBat / https://numenor.health

Dr Mustafa Sultan: https://www.musty.io/

0:00 Intro

0:38 VC Dirty Money (LP Sources)

8:30 Power Dynamics Founder vs VC

12:56 Trillion $ Alzheimer's Opportunity

14:26 Eli Lily's New Alzheimer's Blockbuster (?) Donanemab

19:01 More Issues with Donanemab Phase III Results

21:48 Will Anyone Pay for Donanemab?

24:13 Donanemab Side Effects

27:15 Startup Opportunities in Alzheimer's 

31:34 Outro

Articles Mentioned

Founders need to take a stand against VC's 'dirty money’: https://sifted.eu/articles/founders-vc-dirty-money

Eli Lily Donanemab Phase III Press Release: https://investor.lilly.com/news-releases/news-release-details/lillys-donanemab-significantly-slowed-cognitive-and-functional

Cost Effectiveness of Donanemab: https://pubmed.ncbi.nlm.nih.gov/35344024/

Podcast Links

YouTube: https://www.youtube.com/@bigpicturemedicine

Apple: https://podcasts.apple.com/gb/podcast/big-picture-medicine/id1500446262

Spotify: https://open.spotify.com/show/5707RPmWOJkVZyUHNRSUfS?si=96c7fff6bccb456a

People

Dr Imran Mahmud: https://www.imranmahmud.com/

Dr Adam Bataineh: https://twitter.com/DrAdamBat?s=20

Dr Mustafa Sultan: https://www.musty.io/

Papers Mentioned—

ChatGPT better + more empathetic than human doctors (JAMA Int Med Paper): https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2804309

Detecting eye disease using AI (Nature Biomedical Engineering): https://www.nature.com/articles/s41551-022-00867-5

Predicting dementia using LLMs (PLOS Digital Health): https://pubmed.ncbi.nlm.nih.gov/36812634/

AI recognises race from black and white X rays (Lancet Digital Health): https://www.thelancet.com/journals/landig/article/PIIS2589-7500(22)00063-2/fulltext

VC dirty money article: https://sifted.eu/articles/founders-vc-dirty-money

0:00 Intro 0:30 ChatGPT vs Doctors (JAMA Paper) 15:57 AI Better at Diagnosis than Doctors 30:57 Dirty VC Money 32:02 Audience Feedback Joined by: Dr Adam Bataineh: Longevity doctor and Co-founder Span Health (acquired by EightSleep). Dr Imran Mahmud: Investor, Oxford-trained doctor, ex-Mckinsey and Co-founder of NYE Health. Dr Mustafa Sultan: Creator of Big Picture Medicine and Doctor.

0:00 Intro

0:32 Why are VCs so unhappy?

2:18 What’s hard about being a VC?

3:56 Hustle culture, FOMO, always-on culture in VC

9:54 Is it ever easy to become rich?

12:22 It’s time to build in healthcare

15:31 Why is healthcare so hard for big tech?

17:31 Reasons why healthcare is easier than you think

21:04 Imposter syndrome for tech people entering healthcare

24:03 Would you build another healthcare startup?

25:12 Outro

Joined by:

Dr Imran Mahmud: Investor, Oxford-trained doctor, ex-Mckinsey and Co-founder of NYE Health. 

Dr Mustafa Sultan: Creator of Big Picture Medicine and Doctor.

Martin Shkreli is an American Investor, Pharmaceutical Executive and Hedge Fund Manager who became the most hated man in America in 2015 when he obtained the drug Daraprim and increased its price from $13.50 a pill, to $750 overnight.

0:00 Intro

1:56 The Big Short

8:04 How to price a drug

20:01 Should we price drugs like iPhones

25:36 Pharma's dirty secret with R&D spend

34:12 Why are we not discovering more drugs? Eroom's Law

43:59 Marting's new AI Doctor — Dr Gupta

51:08 What's the FDA going to say?

53:26 Problems with GPT-4; hallucinations and sources

1:00:00 Mental health impact of being the most hated man in America

1:02:30 How rich are you?

1:08:00 Outro

Daraprim is used to treat or prevent parasitic diseases, commonly in patients with HIV or AIDS.

He defended the move by saying “If there was a company that was selling an Aston Martin at the price of a bicycle, and we buy that company and we ask to charge Toyota prices, I don't think that that should be a crime.”

Unrelated to the Daraprim scandal, in 2017 he was charged with securities fraud and sentenced to seven years in prison and fined a total of over $70M dollars.

Martin comes from humble beginnings, his parents are Albanian immigrants — but he quickly ascended the world and became a multimillionaire polymath. And despite having no formal training in Medical Sciences — he has a penchant for consuming medical literature from PubMed, and making novel insights.

We talk about how Martin does this, his philosophy around drug pricing — and whether we should think about pricing drugs in the same way we price iPhones, we talk about whether blowing more money into pharma research & development actually leads to more exciting drugs, Martin’s new AI doctor that he just launched and the mental health impact of being the world’s most hated man.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Ben Maruthappu is the the Co-founder and CEO of Cera Care; a digitally-enabled social care company which has raised over $400M dollars. He was made a Member of the Order of the British Empire in 2020.

0:00 Intro

0:47 Ben's story

6:10 How to have good ideas, at the right time

12:14 Good decisions Ben made with Cera to scale

21:07 Is the US greener pastures?

28:10 What healthtech can learn from fintech, ridesharing and food delivery

30:17 Anti-lessons from other industries

33:53 How do you stop driving becoming toxic

36:13 Are founders olympic athletes who don't deserve work-life balance?

38:31 Are you full of sh*t? What are your real motives?

41:19 Are successful founders happy people?

43:30 Mo money mo problems

46:51 The power of vulnerability vs the magnetism of certainty

52:21 Networking advice

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Ala Alenazi is a TechBio Investor at Ascension and holds a PhD in Molecular Genetics from Cambridge University — she describes herself as a recovering scientist with extreme FOMO.

0:00 Intro

0:47 Being bombastic

3:32 Do PhDs make good VC investors?

10:38 How much of VC is luck?

12:47 Network building in VC

19:16 Getting deal flow

22:15 How to ask for things

24:43 Experience being a brown woman in VC

28:42 No one gives you anything, you just have to take it

33:50 Main character syndrome

We talk about how being bombastic is the key to getting opportunities, why contrary to popular belief — PhDs don’t suck as investors, how to ask people to do things for you and what it’s like being a brown woman in VC.

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

0:00 Intro

0:54 Is AI Too Powerful?

17:59 Outlive, Peter Attia's New Longevity Bible

45:16 Why Are Americans Dying So Young?

Joined by: 

Dr Adam Bataineh: Longevity doctor and Co-founder Span Health (acquired by EightSleep). 

Dr Imran Mahmud: Investor, Oxford-trained doctor, ex-Mckinsey and Co-founder of NYE Health. 

Dr Mustafa Sultan: Creator of Big Picture Medicine and Doctor.

Dr John Whyte is the Chief Medical Officer of WebMD, he’s also worked at Director level at the FDA and was also Chief Medical Expert at the Discovery Channel.

0:00 Intro

0:54 Anxiety as a content creator

2:33 Why should executives think like physicians?

7:23 Decision-making with limited information

10:47 Bayesian reasoning

12:57 Risk, acuity and stress

15:28 What should we NOT learn from physicians?

17:06 Future of health communication, health influencers

22:29 Regulation for health influencers?

24:22 Habit: I've never applied for a job

26:53 Networking building

28:24 Introspection as a habit for success

John runs a course called 'Think Like a Doctor to Make Executive Decisions' — and I ask about different frameworks executives can pick up from doctors and use in non-healthcare settings (such as bayesian reasoning and assessing what is a symptom vs a cause).

John’s also a veteran of the health communication space, and we discuss where the future of health content is going, and the art of storytelling.

John's course: https://www.linkedin.com/learning/think-like-a-doctor-to-make-executive-decisions

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

0:00 Intro

1:00 AI drug development

7:04 Big picture impact of AI drug development

9:14 Counterintuitive facts about drug development

11:06 Why can't we just make novel drugs with AI? Biology is hard

19:06 Microsoft's GPT-4 healthcare play

26:48 The hardest thing about health startups

31:49 Outro

Joined by: 

Dr Adam Bataineh: Longevity doctor and Co-founder Span Health (acquired by EightSleep). 

Dr Imran Mahmud: Investor, Oxford-trained doctor, ex-Mckinsey and Co-founder of NYE Health. 

Dr Mustafa Sultan: Creator of Big Picture Medicine and Doctor.

Dr Shivdev Rao is a Cardiologist and CEO/Co-founder of Abridge, who have raised over $22M.

Think of Abridge like an Alexa or Siri (or other voice assistant) that sits there whilst the physician and patient talk.

Instead of the physician writing notes during the consult, or staying late and charting — Abridge listens to the conversation and writes up the notes for them.

Similarly, instead of the patient frantically taking notes, or being bombarded with information — most of which they will forget — Abridge can send them an appropriately-pitched record of what was said, with key takeaways.

We talk about how Shiv built and grew this company, I ask him about the existential threat of LLMs like ChatGPT, how being in the intensive care unit is similar to building a startup, and how operating from a place of abundance is a key to success.

0:00 Intro

1:35 Shiv's story

8:50 Cross pollination as a tech CEO

12:02 Abridge, idea to execution

17:19 Possibilities with big data

19:53 Threat of LLMs like ChatGPT

23:52 How will Abridge fail?

25:22 How to stay focused

27:10 Leadership lessons

31:14 Habits that have helped Shiv

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

0:00 Intro 

1:27 Semaglutide (Wegovy) lowdown, use in longevity clinics 

6:38 Is a 'pill for everything' a bad thing? 

10:39 What's going to happen to all the DTC weight loss startups? 

13:37 Is Semaglutide a TikTok conspiracy by big pharma? 

14:55 The new alcohol-free alcohol, GABA 

21:07 Where are all the big UK healthtech exits? 

24:16 US investors/entrepreneurs are more ambitious 

27:41 Is DTC digital health the way to go? 

32:40 Is there much point building in the UK?  

Joined by: 

Dr Adam Bataineh: Longevity doctor and Co-founder Span Health (acquired by EightSleep). 

Dr Imran Mahmud: Investor, Oxford-trained doctor, ex-Mckinsey and Co-founder of NYE Health. 

Dr Mustafa Sultan: Creator of Big Picture Medicine and Doctor.

0:00 Intro 

1:09 David Sinclair's New Startup  

11:25 ChatGPT for Drug Development 

28:32 Transhumanist Gene Editing to Sleep Less 

37:38 Banter/Audience Feedback  

Dr Adam Bataineh: Longevity doctor and Co-founder Span Health (acquired by EightSleep). 

Dr Imran Mahmud: Investor, Oxford-trained doctor, ex-Mckinsey and Co-founder of NYE Health. 

Dr Mustafa Sultan: Creator of Big Picture Medicine and Doctor.

Dr Ignacio Medrano is the Founder of Savana (raised $44M dollars with over 100 employees). They use AI to unlock all the value out of clinical records and produce real world evidence.

0:00 Intro

0:34 Ignacio's story

1:30 Learnings from Neurology -> Entrepreneurship

3:27 How to build good health products/services

5:03 Downsides of being a doctor in health entrepreneurship

7:21 Just in case vs just in time learning

9:14 Perils of perfectionism in healthcare

12:34 Do you need to be a d**k to be a good leader?

14:27 Dunbar's number — leading bigger organisations

17:52 Differences in operating in Europe

20:12 Diagnostic medical AI is a waste of time

23:15 SWOT analysis of Savana

26:07 Threats to Savana — LLMs?

29:22 Being eccentric as a competitive advantage

31:09 Becoming a better speaker/storyteller

34:02 Declining Royal Academy of Sciences invite

36:24 Arrogance as a competitive advantage

38:48 Tribes — exclusion criteria importance

40:27 Billion $ Health Idea

41:38 Not watching TV as a competitive advantage

46:40 Outro

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Stephanie Eltz is a Trauma Surgeon and CEO and Co-founder of Doctify, which is basically Yelp/Trustpilot for Doctors. They’ve raised >£22M dollar in funding to date.  

0:00 Intro 

0:41 Story 

2:34 Motivations 

3:47 Building Doctify 

8:25 Why do you have grit? Early childhood 

9:21 Are patient reviews good measures of a doctor? 

13:53 There is no growth hack 

16:34 How to stop reviews becoming a cesspit 

19:48 Monetising 

21:15 It's all about the destination 

22:46 Happiness as a founder 

24:31 Are you full of sh*t? 

26:48 First become a King, then a Philosopher 

28:10 Leadership and MBTI 29:28 Habits 

30:20 Insecurity and immigrant hustle 

33:16 Hustling 

35:00 You don't need to network 

36:17 Outro

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Jason Foster is the CEO of Ori Biotech; a cell and gene therapy company who have raised $139M in funding. He also sits on the boards of companies like GripAble, Credentially, and Auxita — and is an active angel investor.

0:00 Intro 

0:34 Jason's story 

5:31 What was your goal? 

6:39 When did you make it? 

8:31 Taking calculated risks in life 

10:48 Creating value vs chasing $$ 

12:15 When should you say no? 

16:39 How to coach people 

20:53 How to find a coach? 

23:37 How to do cold outreach 

27:16 Being a marketer and making it in biotech 

31:54 Introversion vs extroversion as a CEO/founder 

35:37 How to build professional relationships, Neurolinguistic Programming 

37:54 The founders first zeitgeist 

42:05 Managing your ego 

45:07 Disagreeable givers 

45:39 Why do media? 

46:29 Jason's grand theory 

51:59 Why are health/life sciences/biotech unique markets? 

55:28 Billion dollar health idea 1 

59:57 Billion dollar health idea 2 

1:04:00 Money and happiness 

1:07:50 Habits that have helped Jason

You can find me on Twitter @MustafaSultan and subscribe to my newsletter on www.musty.io

Dr Adam Bataineh is a Longevity Doctor and Founder of Span Health (acquired by EightSleep). 

0:00 Intro 

0:15 Bryan Johnson's Blueprint Program 

12:32 Spotify's Daniel Ek Enters Healthcare 

22:27 VitaDAO Raises $4.1 (from Pfizer, Balaji Srinivasan...)