Host Melissa Kramer interviews Dr. Philippe Zimmern, a leading expert in female pelvic medicine and reconstructive surgery, about bladder fulguration—a lesser-known but potentially transformative treatment for recurrent and chronic UTIs. Dr. Zimmern shares his clinical insights, research findings, and practical guidance on when this procedure is appropriate and how it works.

From discovering hidden bacterial communities in the bladder wall to explaining why some infections return despite antibiotics, this conversation offers a deep look into what’s really going on with persistent UTIs. Learn why modern cystoscopy techniques are changing the game, and how fulguration might help reclaim your bladder health when other treatments fall short.

What You’ll Learn:

• Why standard antibiotics may not be enough: the role of embedded bacteria and biofilms
  
  
  
• What bladder fulguration is, who it's for, and how it’s performed
  
  
  
• What healing looks like post-procedure—including risks, timelines, and patient experience

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel if you prefer video format.

Host Melissa Kramer interviews Dr. Ashley Girard, a naturopathic doctor specializing in chronic UTI treatment, recurrent UTI prevention, and bladder health, on chronic UTI, bladder health, and naturopathic treatment.

Dr. Girard shares how naturopathic medicine offers a personalized, root-cause approach to managing chronic UTIs—prioritizing long-term healing over temporary symptom relief. She highlights the role of herbal remedies, the importance of addressing inflammation, and how individualized care can transform the quality of life for those facing persistent urinary tract infections.

Whether you're seeking alternatives to repeated antibiotic use or looking for sustainable ways to improve your bladder health, this episode is packed with valuable, evidence-based insights.

What You'll Learn:

1. Discover how naturopathic principles—like personalized care and root-cause healing—provide a powerful alternative to standard UTI treatment protocols. Learn how this approach can lead to more sustainable outcomes for chronic UTI sufferers.

2. Get an overview of specific herbal treatments used in naturopathic care for UTIs. Dr. Girard explains their anti-inflammatory and antimicrobial benefits and how these natural therapies can support healing when antibiotics aren’t effective.

3. Take away practical lifestyle strategies to maintain bladder health, minimize flare-ups, and prevent recurrent urinary tract infections—from nutrition and hydration to stress management and microbiome support.

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel if you prefer video format.

Host Melissa Kramer Interviews Dr. Angelish Kumar, a urologist and founder of Women's Urology New York, on Chronic UTI, Bladder Health, and Recurrent Infections

Dr. Kumar unpacks why standard UTI tests frequently fail to detect infections and how advanced diagnostics like PCR testing are reshaping how we understand and treat persistent symptoms. This episode is a must-listen for anyone confused about recurring infections, misdiagnoses, or ongoing urinary symptoms that don’t align with conventional lab results.

Key Takeaways:

• Why traditional UTI testing often misses infections—and how molecular diagnostics like PCR can provide clearer answers.
• How the bladder microbiome functions, and why eliminating all bacteria isn’t necessarily the path to better bladder health.
• The role of overlooked conditions such as Skene’s gland infections or pelvic floor dysfunction in persistent urinary symptoms—and why they require different treatment approaches.
• Tips for advocating for comprehensive care, especially when standard approaches fall short.

This conversation offers much-needed clarity for those navigating chronic UTI, recurrent UTI, or unresolved urinary symptoms—and provides practical insights into more personalized, effective care.

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel if you prefer video format.

Host Melissa Kramer interviews Professor James Malone-Lee on chronic UTI recovery, recurrent UTI treatment protocols, and how symptom flares can be part of long-term bladder health healing.

Chronic UTI recovery is rarely linear, and symptom flare-ups during treatment don't always signal failure. In this enlightening conversation, Professor Malone-Lee, who was a leading voice in urinary tract infection research, explains why symptoms may fluctuate and how a science-backed approach can dramatically improve outcomes for those living with recurrent UTIs and chronic bladder health issues.

The episode dives into how modern treatment protocols, grounded in decades of research, are helping patients find relief, even after years of misdiagnosis or ineffective care.

Listen now to understand how recovery can involve ups and downs—and why staying the course matters.

Key Takeaways from the Episode:

• Symptom flares don’t mean failure—they’re part of the process:
   Recovery from chronic urinary tract infections often follows a “damped oscillation” pattern. This means symptom flare-ups may occur but should reduce frequency and intensity over time, signaling healing rather than relapse.
• Effective treatment requires precision and persistence:
   Antibiotic therapy for chronic UTI must be carefully dosed and often involve specific combinations to reach bacteria embedded deep in bladder tissue. One-size-fits-all treatments often fail to eradicate these hidden infections.
• Standardized protocols outperform outdated methods:
   Professor Malone-Lee explains why evidence-based protocols, rather than culture-based diagnostics, are delivering better results for chronic UTI and recurrent UTI patients. Personalized, protocol-driven treatment improves both short- and long-term bladder health outcomes.

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel if you prefer video format.

Host Melissa Kramer interviews Professor James Malone-Lee, who was a world-renowned UTI specialist on chronic recurrent UTIs, and why standard treatments often fall short in addressing long-term bladder health issues.

Professor Malone-Lee explores the reasons behind persistent urinary tract infections and why short-course treatments frequently fail. Drawing from decades of clinical experience as both an army doctor and academic researcher, he explains how bacteria can hide within bladder cells, remaining active but undetectable, and why a patient-centered, long-term treatment strategy is essential for managing chronic UTI and recurrent UTI.

Tune in to hear how hidden infections, misunderstood symptoms, and outdated testing methods continue to affect those living with chronic urinary health issues.

 Key Takeaways:

• Bacteria can embed themselves inside urothelial bladder cells, becoming intracellular and escaping detection through routine urine culture tests. Despite negative results, symptoms may persist due to this hidden infection process.
• Recovery doesn't always match the timeline of symptoms. Some long-standing UTIs may resolve quickly, while new infections could take longer. Malone-Lee advocates for personalized treatment plans over rigid, short-course approaches.
• Flare-ups can be part of the healing process. As infected bladder cells are shed, bacteria may be released, triggering temporary symptom flares. These episodes aren’t setbacks—they can signal that treatment is working to eliminate the infection at its source.

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel if you prefer video format.

Host Melissa Kramer interviews Dr. Krystal Thomas-White, a leading researcher at Stanford University, to explore the links between chronic UTI, recurrent UTI, and bladder health through the lens of urinary microbiome research.

Dr. Krystal discusses how new findings challenge the long-standing belief that the bladder is sterile. She explains how current diagnostic methods often miss key bacteria, leaving many patients without answers despite persistent symptoms.

This conversation is a must-listen for anyone dealing with ongoing urinary symptoms or navigating the uncertainty of chronic and recurrent UTIs.

Tune in to understand why your symptoms matter—even when your test says otherwise.

 Key Takeaways:

• Standard urine culture tests often only detect E. coli, missing a wide range of other bacteria that may be contributing to infection. As many as 1 in 5 patients with symptoms get a negative result due to these limitations.
• Beneficial bacteria such as Lactobacillus are shared between the vaginal and bladder environments. A healthy vaginal microbiome supports long-term bladder health and can reduce infection risk.
• While probiotics don't reach the bladder directly, they can reduce E. coli in the gut, creating downstream effects that benefit the urinary tract and reduce UTI recurrence.

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel if you prefer video format.

Host Melissa Kramer Interviews Dr. Soman Abraham, a professor of Pathology at Duke University, on Chronic and Recurrent UTIs.

Together, they unpack why some UTIs resolve quickly while others persist or recur, leaving patients in a frustrating cycle of symptoms and treatment. Dr. Abraham shares new insights into how the bladder’s immune system functions and why current antibiotic treatments may fail to eliminate bacteria embedded in bladder tissue. This discussion introduces a promising vaccine that could revolutionize how the immune system targets persistent infections.

This episode is essential listening for anyone struggling with persistent bladder symptoms or searching for science-based answers about UTI prevention, immune dysfunction, and bladder health innovation.

Key Takeaways from This Episode

• How the immune system reacts to a UTI, and why that reaction may not be enough to prevent chronic or recurrent infections.
• Why antibiotics sometimes fail—clearing bacteria from urine but missing those hidden deep in bladder tissue.
• The future of UTI treatment: how a new vaccine may activate T cells in the bladder, offering a more precise and lasting solution for those suffering from chronic UTI.

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel if you prefer video format.

Host Melissa Kramer, founder of Live UTI Free, interviews Dr. Brianne Grogan, a pelvic health expert on Chronic UTI, Pelvic Floor Dysfunction, & Bladder Health.

Dr. Grogan shares her personal journey with pelvic organ prolapse, demystifies the role of pelvic floor muscles in urinary function, and provides practical, body-positive strategies for managing symptoms that often accompany recurrent UTI, such as pelvic tension, incomplete bladder emptying, and discomfort during urination.

Together, Melissa and Dr. Grogan explore how movement, posture, breathing, and daily habits can significantly impact pelvic floor performance and overall urinary wellness, especially for those navigating complex or ongoing bladder conditions.

What You’ll Learn in This Episode:

• Why symptoms of chronic UTI or recurrent UTI can persist even after tests show no infection—and how pelvic floor tension may be the missing link
• The impact of posture, breathwork, and core muscle coordination on pelvic floor health and long-term bladder relief
• How intentional, gentle movement can aid recovery and support the bladder during symptom flare-ups
• Dr. Grogan’s insights into balancing pelvic strength and relaxation for improved urinary outcomes

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel if you prefer video format.

Host Melissa Kramer, founder of Live UTI Free, interviews Dr. Sachin Malde, a consultant urologist with a specialist focus in functional urology, chronic urinary tract infections (UTIs), and bladder pain syndrome, on bladder instillations for chronic and recurrent UTIs.

The discussion explores an increasingly common treatment for those living with chronic UTI and recurrent urinary symptoms: bladder instillations. Dr. Malde explains the science behind intravesical therapy, outlining antibiotic and non-antibiotic bladder instillation options, and how these can relieve symptoms while reducing reliance on long-term oral antibiotics.

The episode provides insight into how bladder instillations are used in clinical practice, including the potential for self-administered treatments at home. 

What You'll Learn in This Episode:

• Why bladder instillations may be safer and more effective than repeated oral antibiotics for chronic UTI treatment
• The differences between antibiotic and non-antibiotic bladder instillations and how to determine which might be appropriate for your symptoms
• How to manage at-home bladder instillations, including tips on treatment frequency, comfort, and results

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel if you prefer video format.

Host Melissa Kramer Interviews Alina Filipe, a leading pelvic floor physiotherapist, on Chronic UTIs and Bladder Health.

Together, they explore the overlooked connection between pelvic floor dysfunction and chronic urinary tract infections, offering practical, evidence-informed insights to help listeners find relief when antibiotics alone aren’t enough.

If you’re frustrated by recurring UTIs, lingering symptoms, or want to understand better the anatomy that affects your bladder health, this episode is essential listening.

Key Takeaways from This Episode:

• Did you know that not fully relaxing your pelvic floor while urinating can increase the risk of a UTI? As Alina points out, “If you're not completely relaxing your pelvic floor, it’s easier to leave some urine behind, which raises your chances of a UTI.”
• Pelvic floor health is about balance, not just strengthening. Alina emphasizes that pelvic floor physiotherapy goes beyond trigger points, addressing hydration, bowel regularity, sexual function, and hygiene practices that may worsen symptoms.
• If UTI symptoms persist after treatment, your pelvic floor may be contributing to the discomfort. “The pelvic floor can become sensitized,” explains Alina, highlighting how nerve irritation and muscle tension can mimic infection symptoms without bacteria. The episode covers gentle techniques to reset the pelvic floor and break the cycle of pain and misdiagnosis.

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel if you prefer video format.

Host Melissa Kramer Interviews Dr. Michael Hsieh, a leading expert in recurrent urinary tract infections (UTIs), bladder health, and urology, to unpack the truth about chronic UTI testing and bladder health.

Dr. Hsieh dives deep into the reliability of standard UTI tests and why they may often present false negatives, especially in people suffering from chronic UTI symptoms. Together, they explore emerging research, the hidden causes of persistent urinary symptoms, and innovative, science-backed alternatives to traditional treatments. Whether you're navigating recurrent UTIs, battling a chronic bladder infection, or seeking preventive strategies, this episode is packed with invaluable insights for anyone serious about understanding and improving their urinary tract health.

Three Key Takeaways:

1. Conventional urine cultures often miss infections. Dr. Hsieh explains the science behind negative UTI test results despite persistent symptoms and how newer methods may offer better detection for chronic UTI sufferers.
2. Explore options like bladder instillations, which deliver medication directly into the bladder, offering targeted relief for recurrent UTIs without over-relying on systemic antibiotics.
3. Simple but powerful changes—like increased water intake, urinary habits, and even dietary shifts—can support long-term bladder health and reduce the risk of recurring infections.

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel if you prefer video format.

Host Melissa Kramer Interviews Dr. Sula Windgassen, a renowned health psychologist and expert in the psychology of chronic illness, on the Mind-Body Connection in Chronic UTI Healing.

Dr. Windgassen opens up about her personal journey with recurrent UTIs and shares how integrating psychological strategies transformed her approach to bladder health and symptom management. This episode delves into the critical yet often overlooked mind-body connection in chronic illness, especially in those navigating chronic UTIs.

Together, Melissa and Dr. Windgassen discuss practical tools for managing anxiety, coping with symptom flare-ups, and maintaining emotional well-being while living with persistent health issues.

What You’ll Learn in This Episode:

• How Stress Impacts Chronic Illness. Discover how hypervigilance and stress can amplify symptoms of chronic UTI and other health conditions—and how mindfulness techniques can rewire your brain’s response to pain.
• The 4-2-6 Breathing Technique. Learn a simple, science-backed breathing method that helps calm your nervous system, reduce anxiety during UTI flare-ups, and shift focus from discomfort to healing.
• Navigating Relationships While Living With Recurrent UTIs. Get expert tips on how to communicate with loved ones about your condition, set boundaries, and rebuild connection—essential tools for emotional and relational resilience.

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel if you prefer video format.

Host Melissa Kramer Interviews Dr. Stewart Bundrick, a renowned specialist in recurrent urinary tract infections (UTIs) and bladder health, on Chronic UTI & Bladder Health

In this compelling episode, Dr. Stewart, who has decades of experience treating chronic UTIs, challenges outdated treatment models and highlights why many patients continue to suffer without lasting relief.

If you're navigating the frustrating cycle of recurrent UTIs or have been diagnosed with Interstitial Cystitis (IC), this episode explores overlooked root causes and alternative treatment strategies that could offer you clarity and hope.

Key Topics Covered:

• How Chronic UTIs Can Persist
  Dr. Bundrick explains how bacteria can become embedded inside bladder cells, making them resistant to standard treatments.
• Why Standard Tests Often Miss Infections
  Learn how traditional urine cultures may fail to detect intracellular or biofilm-based infections, and why symptom-based diagnosis is critical.
• Long-Term Treatment Protocols
  Explore why treating chronic UTIs may require extended antibiotic courses—sometimes lasting a year or more—for full eradication.

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel if you prefer video format.

Host Melissa Kramer speaks to Dr. Angelish Kumar, board-certified urologist and founder of Women's Urology New York, in a powerful continuation of their discussion on chronic UTI, recurrent UTI, and overall bladder health.

Dr. Kumar shares her clinical insights into diagnosing and managing persistent urinary symptoms, pelvic floor dysfunction, and long-term bladder inflammation. This episode offers practical guidance to help you determine whether your symptoms stem from an ongoing infection or post-infection inflammation, and explores multi-modal strategies to finally break the cycle of recurring UTIs.

 Key Takeaways:

• Uncover hidden infections: Learn how diagnostic tools like cystoscopy and advanced urine testing can detect embedded bacteria and bladder wall inflammation that standard tests often overlook.
• Healing beyond antibiotics: Understand why managing chronic UTIs involves more than just prescriptions—considering approaches like cranberry extract, vaginal estrogen therapy, D-mannose, and bladder lining support.
• Bladder-pelvic floor connection: Discover the link between recurrent UTIs and pelvic floor dysfunction, and why pelvic floor physical therapy may outperform antibiotics for some patients.

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel if you prefer video format.

Host Melissa Kramer interviews UK-based nutritional therapist Beverley Sarstedt on the role of nutrition, gut health, and individualized care in the recovery from chronic and recurrent UTIs. Beverley shares her journey from personal health crisis to clinical practice, and how working alongside chronic UTI experts, such as Ruth Kriz and Dr. Jessica Drummond, has shaped her approach. This episode explores the complexities of food sensitivities, microbiome health, histamine overload, and long-term antibiotic use, offering hope and clarity to those navigating persistent urinary symptoms.

Learn more about Beverley’s work atnourishinginsights.com

Listen to learn:

• How food intolerances, SIBO, and histamine issues can mimic or worsen UTI symptoms
  
  
  
• What a bladder-friendly anti-inflammatory diet really looks like—and how to make it sustainable
  
  
  
• The truth about probiotics, fermented foods, and D-mannose: when they help and when they might hurt

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel if you prefer video format.

In this eye-opening episode, host Melissa Kramer interviews Dr. Shaheen Khazali, a specialist who has performed over 4,000 endometriosis surgeries, on the complexities of endometriosis, especially when symptoms overlap with recurrent UTI and bladder pain.

They explore what endometriosis really is, where it can appear (including in the urinary tract), how it may be mistaken for IBS or UTI, and why so many patients go years without a diagnosis. Dr. Khazali also shares current thinking on diagnosis methods, including upcoming biomarker tests, and clarifies the differences between surgical approaches, such as ablation versus excision.

In this episode, you'll learn:

• Why endometriosis symptoms can be mistaken for UTIs, especially during urination or after sexual activity
  
  
  
• The most common and uncommon locations where endometriosis can grow
  
  
  
• How hormone therapy and surgery can affect urinary and reproductive symptoms
  
  
  
• What to ask your doctor if you suspect you may have endometriosis and feel you're not being heard.

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel if you prefer video format.

Host Melissa Kramer interviews Dr. Catriona Anderson, a UK-based women’s health doctor and founder of a diagnostics lab focused on enhanced UTI testing. Together, they explore Hiprex—what it is, how it works, and its potential role in managing recurrent and chronic UTIs.

Dr. Anderson breaks down the science behind this over-the-counter urinary antiseptic, explaining its dual-action mechanism, how it functions as both bactericidal and bacteriostatic, and why it stands out as a non-antibiotic option. The episode also provides practical guidance on taking Hiprex, managing side effects, and combining it safely with other therapies, such as vitamin C, D-mannose, and probiotics.

3 Key Takeaways:

1. Hiprex’s Dual Mechanism Makes It Unique: Hiprex activates in acidic urine and produces formaldehyde, which kills bacteria directly. It also prevents bacteria from multiplying, making it both bactericidal and bacteriostatic.
   
   
   
2. Safer Long-Term Use with Careful Management: Hiprex has fewer side effects than long-term antibiotics and can be used safely for extended periods. Still, dosage and timing may need to be adjusted based on symptoms, pH level, and lifestyle factors.
   
   
   
3. Better Testing is Essential: Standard urine culture often misses infections, especially in chronic cases. Dr. Anderson’s lab uses extended culture methods and more precise sample handling to uncover hidden bacteria.

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel if you prefer video format.

Host Melissa Kramer interviews Dr. Nicholas Sanford, Vice President of Medical Affairs and Assistant Laboratory Director at MicroGenDX, to explore how advanced molecular testing is transforming the landscape of UTI diagnosis. If you’ve ever had UTI symptoms but were told your test was “negative,” this episode explains why standard tests like dipsticks and cultures often miss infections—and what other options are available.

Dr. Sanford shares how MicroGenDX’s qPCR + NGS testing approach offers greater sensitivity and faster results, even detecting bacteria in biofilms or deep within bladder tissue. With over a million urological samples processed, their data is helping shape better care for patients with chronic and recurrent UTIs.

Key Takeaways:

• Learn why cultures and dipsticks can fail, especially for those with chronic symptoms, and how molecular methods pick up what others miss.
• Gain a clear understanding of how this dual method operates, including the detection of resistance genes and biofilm-related infections.
• Understand how to collect your sample properly, why your partner may need testing too, and what to know about testing after antibiotics.

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel for a video format.

Guest host Jess Price, Patient Involvement Advisor at Live UTI Free, sits down with naturopathic doctor Carley Akehurst to unpack a powerful new resource for chronic UTI patients: the My UTI History Form.

As a chronic UTI patient herself, Jess brings the lived experience perspective to this conversation, asking the questions many patients wish they had the confidence or clarity to ask in the clinic. Together, she and Dr. Akehurst explore how this patient-developed form can transform clinical conversations, reduce the emotional weight of sharing your story over and over, and help you advocate for the care you deserve.

🔗 Download the form and explore more tools at liveutifree.com

🎧 What You’ll Learn:

• How to use the My UTI History Form to streamline and strengthen communication with your clinician.
  
  
  
• Why listing your treatment goals can shift the dynamic of your care in empowering ways.
  
  
  
• Practical ways to approach a new clinician with your prepared form, without feeling dismissed or overwhelmed.
  
  
  

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel for a video format.

In this episode of the Live UTI Free Podcast, host Melissa Kramer talks with Professor Chris Harding, Consultant Urological Surgeon at Newcastle upon Tyne Hospitals NHS Foundation Trust and Professor of Urology at Newcastle University.

They explore the VESPER clinical trial, a landmark study for people with recurrent urinary tract infections (RUTIs) who haven’t improved with first-line prevention. Together, they discuss how bladder instillations work at home, why this trial focuses on real-world symptoms rather than lab culture results, who can participate, and how the findings could inform future care guidelines across the UK.

Key Takeaways

• Three prevention options tested side by side. The VESPER trial compares daily oral antibiotics, bladder-administered gentamicin, and GAG-layer replacement therapy, designed to strengthen the bladder’s natural protective coating.
  
  
  
• Targeted treatment results in fewer whole-body side effects. Delivering medicine straight into the bladder keeps it where it’s needed most. In earlier studies, gentamicin wasn’t detected in the bloodstream, suggesting a low risk of systemic side effects.
  
  
  
• Measuring what matters most. Instead of relying on unreliable culture tests, success is defined by symptoms and treatment outcomes, reflecting how people actually experience UTIs in daily life.

If you or someone you support meets the criteria and is in the UK, discuss a referral specifically for the VESPER trial with your GP.

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel for a video format.

In this episode, host Melissa Kramer speaks with Amanda Burkardt and Dr. Mayukh Das from Phiogen, a biotechnology company developing bacteriophage (phage) therapeutics for recurrent urinary tract infections (UTIs). They describe how their novel approach utilizes targeted viruses to eliminate UTI-causing bacteria, without harming the microbiome. You’ll hear how Phiogen’s science tackles the most challenging cases, including chronic and antibiotic-resistant UTIs, and why they’re inviting patients to help shape the future clinical trial that Phiogen will be running.

If you’ve ever wondered whether phage therapy could be a solution for your chronic UTI, especially if you’ve struggled with negative cultures, biofilms, or treatment resistance, this episode is for you.

🎧 What You’ll Learn in This Episode:

• How phage therapy works, and why it’s different from antibiotics
  
  
  
• Why recurrent UTI patients, especially those with antibiotic resistance or biofilms, may benefit most from phage therapy
  
  
  
• What’s happening behind the scenes to bring an “off-the-shelf” phage treatment to clinical trials
  
  
  
• The current limitations (e.g., E. coli-only focus) and plans for expanding phage therapy access
  
  
  
• How YOU can shape the upcoming clinical trial by joining the patient survey

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel for a video format.

In this episode of the Live UTI Free Podcast, Melissa speaks with Dr. Lindsay Burnett, a physician-scientist in urogynecology, about the complex relationship between pelvic floor disorders, the urinary microbiome, and recurrent UTI symptoms.

Dr. Burnett draws from her clinical and research experience to unpack the often misunderstood differences between acute, recurrent, and chronic UTIs. She also explains how urinary symptoms can be influenced by prolapse, incontinence, urethral sensitivity, and even gut health.

This episode is a must-listen for anyone navigating chronic UTI symptoms, especially those who’ve felt dismissed or misdiagnosed. Dr. Burnett offers a patient-centered approach rooted in science and lived experience, addressing the fundamental questions patients ask but rarely get answered.

Key Takeaways:

1. UTI testing and diagnosis are broken, but evolving.
    Standard urine cultures often miss key pathogens, yet they remain the most widely used method. Dr. Burnett explains why this happens and what newer options (like expanded cultures or catheterized samples) can reveal.
   
   
   
2. Pelvic floor disorders can directly impact UTI risk.
    Conditions like prolapse or poor bladder emptying may not cause infections on their own, but they create an environment that makes UTIs more likely and are often overlooked.
   
   
   
3. Care must be collaborative when the evidence is unclear.
    When guidelines don’t reflect patient experiences, clinicians and patients need to “walk into the unknown together,” exploring options like intravesical antibiotics, pelvic floor physical therapy, and trial-and-error treatments based on symptom patterns.

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel for a video format.

In this episode of the LUF podcast, host Melissa Kramer sits down with Dr. Nick Parkinson, Scientific Director at the UK-based Systems Biology Laboratory. Driven by a personal experience with his young daughter’s recurring, culture-negative UTIs, Dr. Parkinson’s team developed a groundbreaking DNA‑based test that bypasses traditional culture and PCR methods. Using nanopore sequencing, they analyze urine and vaginal samples directly, identifying bacteria, yeasts, viruses, plasmids, and phages with precision and speed. 

Standard UTI tests often miss infections entirely. Dr. Nick Parkinson shares how his team used nanopore DNA sequencing to detect hidden bacteria, including rare strains like Tinnitignum charliei, that culture and PCR can’t find. This advanced method reveals not just what's present, but how each strain behaves and resists treatment. He also explains why testing both urine and vaginal samples is crucial for uncovering hidden reservoirs that may be causing recurrent UTIs.

What You’ll Learn from This Episode

• What limits current UTI tests like culture and PCR, and how nanopore sequencing overcomes them.
  
  
  
• Why matching the strain, not just the species, matters for understanding how UTI bugs behave and resist treatment.
  
  
  
• How this tool may reshape both diagnosis and treatment planning, including antibiotic guidance and recognition of underexplored conditions like overgrowth syndromes.

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel for a video format.

Join host Melissa from Live UTI Free as she speaks with Dr. Indira Mysorekar, a pioneer in urinary tract infection research whose lab uncovered how Escherichia coli can hide in reservoirs within the bladder and then re‑emerge to trigger recurrent UTIs. Together, they explore how bladder health differs between people assigned female at birth and those assigned male, how menopause and chronic inflammation increase UTI risk, and what the future of diagnostics and care might look like. Whether you’re battling recurrent UTIs, living with chronic urinary symptoms, or just want to understand the science behind bladder‑health issues, this episode offers insight, support, and actionable ideas grounded in research.

3 Key Takeaways

• Dr. Mysorekar explains that in many recurrent UTI cases, bacteria aren’t simply coming and going; they may persist hidden within bladder tissue in what she calls “quiescent intracellular reservoirs,” then re‑emerge to cause symptoms.
  
  
  
• Chronic bladder inflammation (even in the absence of a classic culture‑positive infection) can damage the bladder’s barrier cells, turning “normal” urine into an irritant and priming the bladder for future infection.
  
  
  
• The “female bladder” (people with female anatomy) is biologically distinct (and under‑researched) compared to the male bladder; menopause and hormone changes significantly raise the risk of recurrent UTIs, so care needs to look beyond “take antibiotics and go home.”

Want to learn more about urinary health? Visit LiveUTIFree.com for expert articles on the latest research, or check out our YouTube channel for a video format.